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导演:李芸婵
女孩四季(关颖)与玛菱(余男)同在一家公司上班、同住一间公寓,一个携带对“肮脏”超级敏感的洁癖基因,另一个则有肥胖基因,必须不停地吃药才能抑制发胖,两人均为无法与他人建立稳定的关系烦恼着。 四季重逢初恋男友食蚁兽(何润东),两人欢欢喜喜再续情缘之时,对方不经意间流露的邋遢令她难以继续往前;玛菱与男友(林依伦)一年见面的次数非常有限,渴望常情的她被隔壁住的阳光男孩小熊(彭于晏)暗恋着。为了收获令自己真正开心的爱情,两人决定服食药物改造基因,之后,她们的基因得到修正,但新的烦恼也接踵而至。Gigi and Marlene, two single women both in their late 20's, work at a bio-technology company, researching and developing medicine to suppress specific genes and observe their effects on the human body. Gigi is born with the "clean-freak" gene and her obsession with keeping things tidy causes problems in her relationships. Marlene, on the other hand, is born with the "fat gene" and needs to regularly take pills to maintain her weight. Marlene panics when she learns that her "anti-fat" pills will be taken off the market. Their personal problems coincide with romantic ones. Marlene grows frustrated maintaining her long-distance relationships via the Internet, and Gigi leaves her boyfriend when she discovers he's cheating on her. One day, Gigi meets Anteater, her college sweetheart, and they start dating again. Things are going well, and Gigi just cannot remember why she had broken up with Anteater until the day they are about to consummate their passion, Gigi discovers Anteater's terrible secret -- he is a first rate slob! Meanwhile, Marlene is oblivious of the feelings Teddy, the landlord's son, has for her. Realising that their own genetic make-up is the cause of their relationship issues, Gigi and Marlene decide to take an "anti-clean gene" pill. Gigi and Marlene no longer care about their own appearances, but will the two women find true love and happiness without the help of technology?